Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis

Pharmacological inhibitors of glycogen synthase kinase 3.

Three closely related forms of glycogen synthase kinase 3 (GSK-3alpha, GSK-3beta and GSK-3beta2) have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. A large body of evidence supports speculation that pharmacological inhibitors of GSK-3 could be used to...

Familial hypertriglyceridemia-induced acute necrotizing pancreatitis: A case report

Acutepancreatitis can infrequently be a life-threatening complication of hypertriglyceridemia. Rarely, hypertriglyceridemia can originate from an inborn genetic error in lipoproteins metabolism. This condition can be manifested by very high serum triglyceride levels (>1000 mg/dl) and a more severe and lethal form of pancreatitis. Here, we present a case of acute pancreatic which was found out t...

Acute emphysematous necrotizing pancreatitis.

A 65 year old diabetic presented to the emergency with complaints of pain in abdomen and vomiting for one day. On clinical examination, there was diffuse tenderness of the abdomen. Investigation revealed Hb-11.3 gm/dl, TLC-15,300 (Neutrophil81%) and random blood sugar -247 mg/dl. USG was unremarkable due to distended bowels. CT of the abdomen with IV contrast showed swollen pancreas with fuzzin...

Tyrosine kinase inhibitors and acute pancreatitis.

Glycogen Synthase Kinase-3

1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...